Comic Book Resources has an interview with Sam Raimi, in which the director talks obliquely about the possibility of a fourth SPIDER-MAN film. Raimi says he will begin working with a screenwriter on the project as soon as the writers’ strike ends. Regarding whether the sequel would proceed from the previous trilogy or chart its own new path, he adds:
If I was writing it I would have a very strong opinion about that, but we’re hiring a writer to come up with his own take. Sony was willing to go either way, we’ll just have to wait and see what the writer comes up with. I think anything’s possible, though.
I mean, there’s been so many different versions, it doesn’t have to follow the movies that we’ve made. I’d very much like to see Tobey Maguire as Spider-Man, so I have a personal interest in that, but certainly anything’s possible. Spider-Man’s such a big character in the comic books that he could endure a lot of different interpretations. You could start over or you could start with a different aspect of the story than I’ve focused on in the pictures I’ve made, we’ll just have to wait and see what the writer comes up with.